Heat Shock Proteins: a Pathogenic Driver and Potential Therapeutic Target in Acute Pancreatitis

• Conditions: Acute Pancreatitis
• Interventions: Diagnostic Test: CT Scan Day 5-7

• Registration Number: NCT03634787
• Lead Sponsor: Vilnius University

Brief Summary

To investigate the role of Heat Shock Proteins in the mechanism of acute severe pancreatitis. In addition to test the potential treatment target of acute pancreatitis.

All patients who present with clinical symptoms of acute pancreatitis are evaluated for the enrollment of the study.

Detailed Description

All patients with acute pancreatitis are evaluated according to modified Atlanta classification acute pancreatitis severity scores.

Blood serum, urine and DNA samples are collected from all patients presented on admission, after 24 hours, 48 hours, 72 hours.

CT is performed in al patients to evaluate necrosis of pancreas Day 5-7 since hospital admission. If necrosis is not present follow-up is stopped.

Study Timeline

• Study Start: 2017-10-20
• Study First Submitted: 2018-07-03
• Status Verified: 2018-08
• Study First Submitted QC: 2018-08-15
• Last Update Submitted: 2018-08-15
• Study First Posted: 2018-08-16
• Last Update Posted: 2018-08-16
• Primary Completion: 2021-12
• Study Completion: 2021-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 280

Inclusion Criteria

• no prior diagnosis of acute pancreatitis
• admission to the hospital within 2 days since the clinical symptoms
• confirmed diagnosis of acute pancreatitis

Exclusion Criteria

• chronic pancreatitis
• pancreatic cancer

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Acute pancreatitis	CT Scan Day 5-7	First time acute pancreatitis. No later than 2 days since the clinical symptoms started.

Primary Outcome Measures

Name	Time	Method
To measure the levels of heat shock proteins in serum and plasma in acute severe pancreatitis settings	2 years	Different molecular weight Heat Shock proteins role while developing acute pancreatitis.

Secondary Outcome Measures

Name	Time	Method
To measure pancreas cells activity while applying Heat Shock Protein inhibitors	2 years	To establish a mechanism explaining the potential use of heat shock proteins inhibitors/ activators for treatment of acute pancreatitis

Trial Locations

Locations (1)

Vilnius University Hospital "Santaros Klinikos; 🇱🇹 Vilnius, Lithuania