Study of Heat Shock Proteins as Prognostic Factor of Acute Renal Failure in Children (HSP-Study)
- Conditions
- Kidney Failure, Acute
- Registration Number
- NCT00230412
- Lead Sponsor
- University of Munich Children's Clinic
- Brief Summary
The purpose of the investigators' study is to determine whether the production of heat shock proteins has an effect on the development and the outcome of acute renal failure in children.
- Detailed Description
A prognostic factor for the development of acute renal failure (ANR) in children would be very valuable for therapy regulation. So-called chaperones out of the family of heat shock proteins (HSP) are promising candidates which are involved in the development of ANR as well. This could be a starting point for the development of new therapeutic approaches.
ANR occurs in up to 50 percent of all critical ill patients and has a high rate of morbidity and mortality despite advances in symptomatic therapy. Following severe sepsis, septic shock or other shocks, combined with multiple organ failure, the ANR is an autonomous prognosis worsening factor.
Should the results of our study show a correlation between the production of HSP and the outcome of children with ANR, further studies would be required, to examine the pathophysiological relevance of HSP in ANR. We would then be able to determine a high risk population for ANR. A modulation of ANR therapy might be a result of further studies.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
- Between 0 and 18 years of age.
- Either severe sepsis, shock of any origin or asphyxia.
- Operated patients with operative or post-operative transfusion requirement of at least 0.5 x 80 ml/kg body weight of erythrocyte concentrate.
- Existing affection of the kidney.
- Kidney transplantation.
- Missing written consent of the parents or guardian (if applicable).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Acute renal failure. 28 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (6)
Klinikum Augsburg, II. Klinik für Kinder und Jugendliche
🇩🇪Augsburg, Bavaria, Germany
Deutsches Herzzentrum München
🇩🇪Munich, Bavaria, Germany
Kinderklinik Rosenheim
🇩🇪Rosenheim, Bavaria, Germany
Kinderklinik Memmingen
🇩🇪Memmingen, Bavaria, Germany
Klinkum der Barmherzigen Brüder St. Hedwig
🇩🇪Regensburg, Bavaria, Germany
Klinikum der Universität München, Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital
🇩🇪Munich, Bavaria, Germany