THE CLINICAL VALUE OF COMBINED FDG PET/CT IMAGING IN RESPONSE EVALUATION AFTER RADIOCHEMOTHERAPY IN PATIENTS WITH POTENTIALLY OPERABLE LOCALLY ADVANCED HEAD AND NECK SQUAMOUS CELL CARCINOMA
Completed
- Conditions
- head and neck cancerhead and neck squamous cell carcinoma10038666
- Registration Number
- NL-OMON36288
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
operable N2/N3 squamous cell carcinoma of head and neck
planned treatment of chemoradiation (with curative intent)
Exclusion Criteria
Age < 18 years
Pregnancy
Physical condition contra-indication for neck dissection
Inoperable tumour in neck
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The negative predictive value (NPV) of FDG PET/CT for detecting residual nodal<br /><br>involvement</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. The sensitivity and specificity of high-resolution FDG PET/CT<br /><br>2. The sensitivity and specificity of dual time point FDG PET/CT<br /><br>3. The number of additional distant metastases found on PET and the % change in<br /><br>patient management<br /><br>4. DFS and OS, correlation with baseline SUV, early PET response and with HPV<br /><br>status</p><br>