Cognitive function in relation to cerebral blood flow regulation after preeclampsia
Recruiting
- Conditions
- cognitive dysfunction after preeclampsia100269081000984110057166
- Registration Number
- NL-OMON33668
- Lead Sponsor
- Academisch Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Women who have been diagnosed with severe (clinical admission indispensable) early (< 34 weeks) preeclampsia 0.5-1.5 years ago in their first pregnancy.
Age > 18 years
Informed consent of the patient before participation into the study.
Exclusion Criteria
Neurological or cerebrovascular disorders in case history
Kidney function disorder
Use of statines
Psychiatric case history or state (As I and II issues)
Diabetes
Use of anti-depression medicine
Abuse of alcohol and/or drugs.
Smoking or refrained from smoking less than 2 years
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Presence of cognitive complaints<br /><br>Neuropsychological test (NPO) scores to map cognitive function<br /><br>Cerebrovascular control system parameters: NVC-response parameters and<br /><br>parameters describing cerebral autoregulation, in particular in parameters<br /><br>describing the dynamic aspects of the response. For NVC this is damping, rise<br /><br>time and natural frequency and for cerebral autoregulation this is gain and<br /><br>phase as a function of signal frequency<br /><br>Correlation between degree of disturbance of the cerebrovascular control system<br /><br>and cognitive function in former preeclamptic patients.<br /><br>Correlation between presence of cognitive complaints and cognitive function<br /><br>(NPO-scores).<br /><br>Correlation between presence of cognitive complaints and cerebrovascular<br /><br>control parameters.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Pulse wave velocity and pulse pressure as a determinant of arterial vessel<br /><br>stiffness<br /><br>Results of standard duplex -investigation </p><br>