Improving the Nutrition Status of Infants in South-Western Uganda

Not Applicable

Completed

• Conditions: Infant Malnutrition; Nutrition Knowledge; Cognitive Development; Growth
• Interventions: Other: Improving nutrition knowledge among mothers

• Registration Number: NCT02098031
• Lead Sponsor: University of Oslo

Brief Summary

Undernutrition and growth restriction due to poor diet and inadequate nutrient intake continues to be a global challenge, particularly in the developing countries including Uganda. The etiology of inadequate nutrient supply to infants may relate to lack of resources or knowledge or a combination of both. Poor nutrient intake and impaired growth may affect brain and cognitive development.

This study aims to evaluate nutrient intake, growth and cognitive function among children between 6 and 36 months living in the fertile Kabale and Kisoro region in south-western Uganda. The investigators hypothesize that nutrition education to mothers can bring about improved dietary intake and nutritional status among children aged 6-36 months.

A follow-up study was conducted during the period January - July 2022.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03
• Study First Submitted: 2014-03-21
• Study First Submitted QC: 2014-03-24
• Study First Posted: 2014-03-27
• Primary Completion: 2016-08
• Study Completion: 2016-08
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-17
• Last Update Posted: 2024-11-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 511

Inclusion Criteria

• A lead caretaker with a 6-8 months infant (child/lead caretaker pair) who will have given consent to participate in the study. If there is more than one child of the age in the household, the younger one will be taken as the index/study child.

Exclusion Criteria

• Is older than 8 months at baseline
• Congenital malformations or physical handicap that may influence growth or interfere with taking of anthropometric measurements
• Disability that will influence nutrient intake
• Been diagnosed with mental or brain illness as evidenced by mother or health worker.
• If the family that is likely to emigrate during the study period

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
intervention	Improving nutrition knowledge among mothers	Nutritional intervention (nutrition education)

Primary Outcome Measures

Name	Time	Method
Change in the prevalence of stunting (<-2 SD of the WHO, 2006 growth reference standards)	6-8, 12-16, 20-24 (main outcome time point), 36 months, 7-10 years	The investigators will measure the change in stunting between the three indicated time points.

Secondary Outcome Measures

Name	Time	Method
Oral health	7-10 years	The investigators will assay caries using photographs
Change in mean weight-for-age z-score	6-8, 12-16 and 20-24, 36 months, 7-10 years	The investigators will measure the change in mean weight for age z-score between the three indicated time periods.
Change in mean weight-for-height z-score	6-8, 12-16, 20-24, 36 months, 7-10 years	The investigators will measure the change in mean weight for height z-score between the three indicated time periods.
Change in mean diet diversification score (DDS)	6-8, 12-16, 20-24, 36 months	The investigators will measure the change in DDS between the three indicated time periods.
Change in The Kaufman Assessment Battery for Children (2nd ed.; KABC-II) and the Test of Variable of Attention (TOVA)	7-10 years	The investigators will measure the change in the scores of these tests at indicated time periods.
Change in Bayley Child Development test 3 ed.	6-8, 12-16, 20-24, 36 months	The investigators will measure the change in Bayley Child Development test 3 ed. between the three indicated time periods.
Change in gut microbiota	20-24, 36 months, 7-10 years	Fecal samples will be collected and the investigators will measure the change in gut microbiota between the three indicated time periods.
Change in Becks Depression Inventory II questionnaire to determine the maternal self-reported depression symptoms	7-10 years	The investigators will measure the change in this test between the two groups at indicated time periods
Change in Mullens test	36 months	The investigators will measure the change in Mullens test between the two groups after 36 months.
Change in the Center for Epidemiological Studies Depression Scale questionnaires to determine the maternal self-reported depression symptoms	7-10 years	The investigators will measure the change in this test between the two groups at indicated time periods
Change in mean Mid Upper Arm Circumference (MUAC) z-score	6-8, 12-16, 20-24, 36 months, 7-10 years	The investigators will measure the change in MUAC between the three indicated time periods.
Change in Ages and Stages Questionnaire Scores (AQS)	6-8, 12-16, 20-24, 36 months	The investigators will measure the change in AQS between the three indicated time periods.
Change in oral microbiota	36 months, 7-10 years	Saliva samples will be collected and the investigators will measure the change in oral microbiota at indicated time periods.

Trial Locations

Locations (1)

Kyambogo University; 🇺🇬 Kampala, Uganda