Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Obese Males
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- change in stroke volume
研究概览
简要总结
This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation. It is hypothesized that acute dietary supplementation with grape seed extract attenuates aortic stiffness, systolic blood pressure, diastolic blood pressure, mean arterial pressure, and total peripheral resistance and these effects are partially due to reductions in peripheral vasoconstriction
详细描述
Twenty men (obese = 10; normal body weight (NBW) = 10) participated in this study. Effects of placebo (PL: 600 mg) and GSE (600 mg) on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total peripheral resistance (TPR), and AoS were compared 2 h after ingestion of GSE or PL on different days, one week apart. Arterial blood pressure was measured using a sphygmomanometer from a brachial artery at the level of the heart on chair. HR and SV were continuously measured using a non-invasive device (Physio Flow). CO was calculated by HR X SV. TPR was calculated by MAP/CO.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
盲法说明
Double blind, cross-over design
入排标准
- 年龄范围
- 18 Years 至 29 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Obesity: body mass index (>30), Normal body weight: body mass index (25-29)
排除标准
- •cardiovascular diseases or consume any antihypertensive medication or supplementation that can affect blood pressure or aortic stiffness
结局指标
主要结局
change in stroke volume
时间窗: 2 hours after each supplementation
volume per stroke
change in heart rate
时间窗: 2 hours after each supplementation
beats per minute
change in cardiac output
时间窗: 2 hours after each supplementation
total volume for a minute
change in total peripheral resistance
时间窗: 2 hours after each supplementation
One reported value (mean arterial pressure/cardiac output)
change in systolic blood pressure
时间窗: 2 hours after each supplementation
pressure exerted during contraction
change in mean arterial pressure
时间窗: 2 hours after each supplementation
One reported pressure (systolic blood pressure-diastolic blood pressure)/3 + diastolic blood pressure
change in diastolic blood pressure
时间窗: 2 hours after each supplementation
pressure exerted during relaxation
次要结局
未报告次要终点
研究者
Jong-Kyung Kim
Associate Professor
California Baptist University