Effect of Acute Dietary Supplementation With Grape Seed Extract on Aortic Stiffness, Arterial Pressure, and Blood Vessel Dilation in Collegiate Obese Individuals at Rest

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Dietary Supplement: Grape seed extract

• Registration Number: NCT04389060
• Lead Sponsor: California Baptist University

Brief Summary

This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation. It is hypothesized that acute dietary supplementation with grape seed extract attenuates aortic stiffness, systolic blood pressure, diastolic blood pressure, mean arterial pressure, and total peripheral resistance and these effects are partially due to reductions in peripheral vasoconstriction

Detailed Description

Twenty men (obese = 10; normal body weight (NBW) = 10) participated in this study. Effects of placebo (PL: 600 mg) and GSE (600 mg) on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total peripheral resistance (TPR), and AoS were compared 2 h after ingestion of GSE or PL on different days, one week apart. Arterial blood pressure was measured using a sphygmomanometer from a brachial artery at the level of the heart on chair. HR and SV were continuously measured using a non-invasive device (Physio Flow). CO was calculated by HR X SV. TPR was calculated by MAP/CO.

Study Timeline

• Study Start: 2019-03-01
• Primary Completion: 2020-03-01
• Study Completion: 2020-03-01
• Status Verified: 2020-05
• Study First Submitted: 2020-05-08
• Study First Submitted QC: 2020-05-11
• Last Update Submitted: 2020-05-11
• Study First Posted: 2020-05-15
• Last Update Posted: 2020-05-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• Obesity: body mass index (>30), Normal body weight: body mass index (25-29)

Exclusion Criteria

• cardiovascular diseases or consume any antihypertensive medication or supplementation that can affect blood pressure or aortic stiffness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo group	Grape seed extract	Subjects took a single dose of 600 mg starch in capsule form through ingestion 2 hours prior to testing
GSE group	Grape seed extract	Subjects took a single dose of 600 mg GSE in capsule form through ingestion 2 hours prior to testing

Primary Outcome Measures

Name	Time	Method
change in stroke volume	2 hours after each supplementation	volume per stroke
change in heart rate	2 hours after each supplementation	beats per minute
change in cardiac output	2 hours after each supplementation	total volume for a minute
change in total peripheral resistance	2 hours after each supplementation	One reported value (mean arterial pressure/cardiac output)
change in systolic blood pressure	2 hours after each supplementation	pressure exerted during contraction
change in mean arterial pressure	2 hours after each supplementation	One reported pressure (systolic blood pressure-diastolic blood pressure)/3 + diastolic blood pressure
change in diastolic blood pressure	2 hours after each supplementation	pressure exerted during relaxation

Trial Locations

Locations (1)

California Baptist University; 🇺🇸 Riverside, California, United States