Preoperative Vitamin D Levels and Respiratory Complications of General Anesthesia

Not Applicable

Completed

• Conditions: Vitamin D Deficiency
• Interventions: Other: Vitamin D

• Registration Number: NCT03342651
• Lead Sponsor: T.C. ORDU ÜNİVERSİTESİ

Brief Summary

Vitamin D deficiency is a commonly observed health problem in the world. With a role in many chronic diseases and especially lung diseases, the importance of vitamin D deficiency in anesthesia management is increased. This research aims to investigate whether there is a correlation between the respiratory complications occurring in patients under general anesthesia and preoperative vitamin D levels.

Detailed Description

This study included 95 adult cases aged from 18-65 years operated under general anesthesia. The cases had total 25-hydroxyvitamin D (25OHD) levels identified in blood samples before the operation. Patients given routine general anesthesia and postoperative monitoring procedures were assessed in terms of respiratory complications during anesthesia induction, extubation, anesthesia recovery and the first 24 hours postoperative.

This research observed that patients with low preoperative 25OHD vitamin levels encountered respiratory complications related to general anesthesia more often. Especially in the early postoperative period there is a very significant difference between complications and low 25OHD vitamin levels. Our study results show that low vitamin D levels may be a potential risk in terms of respiratory complications related to general anesthesia causing severe morbidity and mortality increase. The results lead to the consideration that optimizing vitamin D levels in the preoperative period for patients undergoing general anesthesia may aid in reducing complications.

Study Timeline

• Study Start: 2015-04-01
• Primary Completion: 2016-04-01
• Study Completion: 2016-12-31
• Study First Submitted: 2017-10-08
• Status Verified: 2017-11
• Study First Submitted QC: 2017-11-13
• Last Update Submitted: 2017-11-13
• Study First Posted: 2017-11-17
• Last Update Posted: 2017-11-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 95

Inclusion Criteria

• American Society of Anesthesiologists I - II risk classification, healthy adult surgery cases

Exclusion Criteria

• Thoracic surgery, those with severe respiratory, neuromuscular or endocrine system diseases, those with difficult intubation, morbid obesity, using vitamin D supplements and those who smoked

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Observational research	Vitamin D	Vitamin D levels and respiratory complications; observational research.

Primary Outcome Measures

Name	Time	Method
Relationship between Vitamin D levels and respiratory complications	Perioperative period	Low vitamin D levels may be a potential risk in terms of respiratory complications related to general anesthesia