Specifying cognition, social interaction and autism-like traits in Fragile X

Recruiting

• Conditions: Fragile X Syndrome; FXS; 10083624; 10057167; 10012562

• Registration Number: NL-OMON46517
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

Children aged 6-18 years, (corrected to) normal vision, Dutch as first language. Four groups of 55 participants are included.
Two groups of mothers (n<=40 per group) will be included, mothers of children in the FXS and in the TD group.
Group specific in- and exclusion criteria are provided in section 4.2 and 4.3 of the research protocol.

Exclusion Criteria

Four groups of participants are included. Group specific in- and exclusion criteria are provided in section 4.2 and 4.3 of the research protocol.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>For the three domains, the main study parameters are:<br /><br>- ASD severity: ASD severity scores from structured behavioral observations.<br /><br>- cognitive abilities: IQ, measured using an age-appropriate IQ test.<br /><br>- (neuro)biological characteristics: brain activation patterns measured using<br /><br>fNIRS.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Our secondary parameters will be: Biological measures (i.e. eye-movements and<br /><br>FMRP levels; see section 8.3 for an extensive description of all assessments<br /><br>and outcomes).</p><br>