SVV and PPV Predict Fluid Responsiveness in Mechanically Ventilated Elderly Patients Under General Anesthesia

Not Applicable

• Conditions: Stroke Volume Variation; Pulse Pressure Variation; Fluid Therapy; Fluid Responsiveness
• Interventions: Diagnostic Test: volume expansion

• Registration Number: NCT04388995
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

Although individualized or goal-directed approach has been advocated, a reliable index is still required to help monitor the volume status timely and efficiently. Dynamic indexes, such as pulse pressure variation (PPV) and stroke volume variation (SVV), have been shown to be clearly superior to more commonly measured static preload variables, such as pulmonary artery occlusion pressure (PAOP) and central venous pressure (CVP). The reliability of dynamic indexes in monitoring the volume status and predicting fluid responsiveness have been validated. Fluid optimization guided by SVV and PPV is beneficial to hemodynamic stability and can decrease mortality and reduce postoperative complications. However, the usefulness of dynamic indexes in elderly patients has not been previously investigated. This study aimed to evaluate whether dynamic indexes PPV and SVV can reliably predict fluid responsiveness in elderly patients, and to determine their thresholds in elderly patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-05-11
• Study Start: 2020-05-12
• Study First Submitted QC: 2020-05-13
• Study First Posted: 2020-05-15
• Status Verified: 2020-08
• Last Update Submitted: 2020-08-25
• Last Update Posted: 2020-08-26
• Primary Completion: 2020-08-31
• Study Completion: 2020-08-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 1.Patients undergoing gastrointestinal surgery 2.Age between 18 and 80 3.ASA I ~II. 4.BMI 18 ~ 24 kg/m2

Exclusion Criteria

• 1.arrhythmias 2.intracardiac shunts 3.severe hypertension (SBP ≥ 160 mmHg or DBP ≥ 100 mmHg) 4.pulmonary hypertension 5.chronic obstructive pulmonary disease 6.peripheral vascular obstructive disease 7.receiving long-term treatment with vasopressors.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
observed patients	volume expansion	-

Primary Outcome Measures

Name	Time	Method
Fluid responsiveness	immediately after the fluid therapy	Fluid responsiveness was defined as an increase in CI ≥15%

Trial Locations

Locations (1)

Chinese PLA General Hospital; 🇨🇳 Beijing, Haidian, China