NCT04679259已完成不适用
Evaluation of Blood Biomarkers as an Indicator of Delayed Neurocognitive Recovery After Cardiac Surgery
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery
研究概览
简要总结
Delayed neurocognitive recovery is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine racemase in blood as an indicator of delayed neurocognitive recovery after cardiac surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for elective cardiac surgery
排除标准
- •MMSE <24
- •History of psychological or neurological diseases
- •Illiteracy
- •Preoperative delirium
- •Vision and hearing impairment
结局指标
主要结局
Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery
时间窗: At 1, 2, and 7 day after surgery
Blood level of D-Amino Acid Oxidase is assessed.
次要结局
- Concentration of D-serine in blood(At 1, 2, and 7 day after surgery)
- Concentration of Serine in blood(At 1, 2, and 7 day after surgery)
- The incidence of postoperative delirium(Daily for 7 days after surgery)
- The incidence of postoperative cognitive dysfunction(At 7 day after surgery)
研究者
Jin-Young Hwang
Associate professor
SMG-SNU Boramae Medical Center
研究点 (1)
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