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Clinical Trials/NCT04679259
NCT04679259
Completed
Not Applicable

Evaluation of Blood Biomarkers as an Indicator of Delayed Neurocognitive Recovery After Cardiac Surgery

SMG-SNU Boramae Medical Center0 sites82 target enrollmentJanuary 6, 2021
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ConditionsPostoperative Cognitive Dysfunction

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Postoperative Cognitive Dysfunction
Sponsor
SMG-SNU Boramae Medical Center
Enrollment
82
Primary Endpoint
Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery
Status
Completed
Last Updated
3 months ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

Delayed neurocognitive recovery is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine racemase in blood as an indicator of delayed neurocognitive recovery after cardiac surgery.

Registry
clinicaltrials.gov
Start Date
January 6, 2021
End Date
October 29, 2025
Last Updated
3 months ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Jin-Young Hwang

Associate professor

SMG-SNU Boramae Medical Center

Eligibility Criteria

Inclusion Criteria

  • •Patients scheduled for elective cardiac surgery

Exclusion Criteria

  • •MMSE \<24
  • •History of psychological or neurological diseases
  • •Illiteracy
  • •Preoperative delirium
  • •Vision and hearing impairment

Outcomes

Primary Outcomes

Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery

Time Frame: At 1, 2, and 7 day after surgery

Blood level of D-Amino Acid Oxidase is assessed.

Secondary Outcomes

  • Concentration of D-serine in blood(At 1, 2, and 7 day after surgery)
  • Concentration of Serine in blood(At 1, 2, and 7 day after surgery)
  • The incidence of postoperative delirium(Daily for 7 days after surgery)
  • The incidence of postoperative cognitive dysfunction(At 7 day after surgery)

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