NCT04679259Unknown不适用
Evaluation of Blood Biomarkers as an Indicator of Postoperative Cognitive Dysfunction After Cardiac Surgery
适应症
干预措施
试验速览
- 阶段
- 不适用
- 入组人数
- 149
- 试验地点
- 1
- 主要终点
- Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery
研究概览
简要总结
Postoperative cognitive dysfunction is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine in blood as an indicator of postoperative cognitive dysfunction after cardiac surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for elective cardiac surgery
排除标准
- •MMSE <24
- •History of psychological or neurological diseases
- •Illiteracy
研究组 & 干预措施
Cardiac surgical patients
Experimental
干预措施: Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood (Diagnostic Test)
Cardiac surgical patients
Experimental
干预措施: Neurocognitive test (Diagnostic Test)
Cardiac surgical patients
Experimental
干预措施: Assessment of delirium (Diagnostic Test)
结局指标
主要结局
Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery
时间窗: At 1, 2, and 7 day after surgery
Blood level of D-Amino Acid Oxidase is assessed.
次要结局
- Concentration of D-serine in blood(At 1, 2, and 7 day after surgery)
- Concentration of Serine in blood(At 1, 2, and 7 day after surgery)
- The incidence of postoperative delirium(Daily for 7 days after surgery)
- The incidence of postoperative cognitive dysfunction(At 7 day after surgery)
研究者
Jin-Young Hwang
Associate professor
SMG-SNU Boramae Medical Center
研究点 (1)
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