NL-OMON39216招募中不适用
Search for genetic variations in neuropsychiatric disorders - GEZIN study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,160
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •A. Inclusion criteria for probands
- •1. All subjects must give signed, informed consent.
- •2. Probands must have a DSM-IV consensus diagnosis of primary psychotic disorder or mood disorder with psychotic features (schizophrenia, schizoaffective disorder, delusional disorder, bipolar I disorder, psychotic depression, post-partum psychosis). A concurrent diagnosis of idiopathic seizure disorder or learning disability will not be an exclusion factor. Accordingly, subjects with mild MR (as determined clinically, FIQ>=55) will be included, if their psychiatric symptoms and history can be clearly established.
- •3. Subjects must be over 18 years of age at interview, male or female.;B. Inclusion criteria for informants
- •1. The informant will have known the subject for at least two years, be familiar with their psychiatric history, and have at least one hour of contact per week with the proband (first-degree family members preferred). As for the probands, informants must give signed, informed consent and be over 18 years of age at interview.
- •2. Exclusion criteria are the same as for the probands given above.;C. Inclusion criteria for family members of probands
- •1. First-, second-, or third degree biological family member of participating probands. As for the probands, family members must give signed, informed consent and be over 18 years of age at interview.
- •2. Exclusion criteria are the same as for the probands given above.
- •3. Family members may, but are not required, to meet criteria for a DSM-IV consensus diagnosis of primary psychotic disorder or mood disorder with psychotic features.
排除标准
- •1. Unable to give informed consent to all aspects of the study.
- •2. Unable to speak and be interviewed in Dutch or English (to ensure validity of the interviews).
- •3. Psychosis is deemed secondary to substance use by the consensus diagnostic procedure because psychotic symptoms are limited to periods of likely intoxication or withdrawal, or there are persistent symptoms which are likely to be related to substance use (i.e., increasing paranoia after years of amphetamine use; symptoms limited to visual hallucinations after extensive hallucinogen use).
- •4. The seizure disorder is deemed secondary to causative factors, such as medication (e.g., clozapine), head injury, psychogenic polydispsia, or alcohol withdrawal.
- •5. Subjects with severe mental retardation (MR).
研究者
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