The Relationship Between Continuous Renal Replacement Therapy, Mortality, and Hospital Length of Stay in Critically Ill Burn Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 238
- 试验地点
- 1
- 主要终点
- RIFLE criteria classification at CRRT initiation
研究概览
简要总结
This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT). Primary endpoints include the evaluation of RIFLE criteria, timing of CRRT initiation, and overall survival. Secondary endpoints consist of comorbidity status, requirement for mechanical ventilation, inotropic support, and hospital length of stay among non-survivors.
详细描述
Severe burn injury is frequently complicated by acute kidney injury (AKI), which is associated with high morbidity and mortality in intensive care settings. Continuous renal replacement therapy (CRRT) is often required in this patient population; however, the prognostic factors influencing survival remain incompletely defined.
In this retrospective study, we analyzed critically ill burn patients who required CRRT. The primary outcomes were the RIFLE classification at the time of CRRT initiation, the timing of therapy initiation, and patient survival. The secondary outcomes included the presence of comorbidities, the need for mechanical ventilation, inotropic support, and length of hospital stay in non-survivors.
By systematically evaluating these clinical parameters, the study aims to clarify the prognostic impact of CRRT in burn patients and to contribute evidence for optimizing the management of acute kidney injury in this critically ill population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18 years and older
- •Admitted to and treated in the Burn Intensive Care Unit
排除标准
- •Patients with an ICU stay of less than 24 hours
- •Patients younger than 18 years
- •Patients with known chronic kidney disease or history of kidney transplantation
- •Patients admitted with toxic epidermal necrolysis (TEN)
- •Patients with estimated glomerular filtration rate (eGFR) ≤ 15 mL/min/1.73m² at admission
结局指标
主要结局
RIFLE criteria classification at CRRT initiation
时间窗: Baseline( Day0, at CRRT initiation)
Patients receiving CRRT will be classified according to the RIFLE criteria (Risk, Injury, Failure, Loss, End-stage kidney disease) at the time of CRRT initiation. The distribution across categories will be analyzed.
Timing of CRRT initiation
时间窗: Baseline( Day0, at CRRT initiation, recorded from patient medical records)
Date and time of initiation of continuous renal replacement therapy (CRRT), obtained from patient medical records.
Survival status of patients
时间窗: At hospital discharge ( end of hospitalization)
Survival versus non-survival status at the end of hospitalization.
次要结局
- Presence of comorbidities in non-survivors(Baseline( Day0, at hospital admission))
- Requirement for mechanical ventilation in non-survivors(Through ICU stay, up to hospital discharge (or death))
- Requirement for inotropic support in non-survivors(Through ICU stay, up to hospital discharge or death)
- Hospital length of stay in non-survivors(From hospital admission through study completion( up to discharge or death))
研究者
Pinar Timur Tasci
Resident Physician, Department of Anesthesiology and Reanimation
Dr. Lutfi Kirdar Kartal Training and Research Hospital