Dairy Intake and Brain Health in Aging

Completed

• Conditions: Aged Healthy Volunteer

• Registration Number: NCT02245035
• Lead Sponsor: University of Kansas Medical Center

Brief Summary

The purpose of this study is to learn if dairy food consumption may help brain health in aging by protecting nerve cells from oxidative damage.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10
• Primary Completion: 2013-11
• Study First Submitted: 2014-09-15
• Study First Submitted QC: 2014-09-17
• Study First Posted: 2014-09-19
• Study Completion: 2014-12
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-19
• Last Update Posted: 2017-03-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Males and females between 60-85 years of age.
2. Good general health with no concomitant diseases, which would be expected to interfere with the study
3. BMI range 20-35 kg/m2

Exclusion Criteria

1. Presence of any central neurological disease with the potential to impair cognition(e.g., brain tumor, stroke, epilepsy, motor neuron disease, multiple sclerosis, Alzheimer disease, Parkinson's disease) or prior major head trauma with loss of consciousness
2. Presence of an active unstable and life-threatening systemic illness (e.g., cancer)
3. Presence of major psychiatric disorder within the past 3 years including depression, anxiety, and alcohol (over 3 drinks per day or total of 18 per week) or drug abuse (DSM-IV criteria; Geriatric Depression Score>6)
4. Presence of diabetes mellitus (defined as a clinical diagnosis or use of an anti-diabetic agent) and metabolic syndrome
5. Use of psychoactive and investigational medications
6. Subjects with MRI contraindications such as pacemaker, aneurysm clips, artificial heart valves, metal fragments, foreign objects or claustrophobia. All subjects subjects will receive a structural MRI as part of this study. Individuals with evidence of infection, infarction, neoplasm or other lesions will be excluded. Individuals found to have abnormalities in their structural MRI will be referred to their primary physician for further evaluation and management.
7. Pregnancy
8. Special diet regimens such as lactose free or vegan

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dietary dairy food intake measured using 7-day diet recording	1 week, prior to MRS scan
Cerebral glutathione (GSH) levels measured by magnetic resonance spectroscopy (MRS)	Baseline

Trial Locations

Locations (1)

University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States