NCT02245035已完成不适用
Dairy Intake and Brain Health in Aging
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Dietary dairy food intake measured using 7-day diet recording
研究概览
简要总结
The purpose of this study is to learn if dairy food consumption may help brain health in aging by protecting nerve cells from oxidative damage.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and females between 60-85 years of age.
- •Good general health with no concomitant diseases, which would be expected to interfere with the study
- •BMI range 20-35 kg/m2
排除标准
- •Presence of any central neurological disease with the potential to impair cognition(e.g., brain tumor, stroke, epilepsy, motor neuron disease, multiple sclerosis, Alzheimer disease, Parkinson's disease) or prior major head trauma with loss of consciousness
- •Presence of an active unstable and life-threatening systemic illness (e.g., cancer)
- •Presence of major psychiatric disorder within the past 3 years including depression, anxiety, and alcohol (over 3 drinks per day or total of 18 per week) or drug abuse (DSM-IV criteria; Geriatric Depression Score>6)
- •Presence of diabetes mellitus (defined as a clinical diagnosis or use of an anti-diabetic agent) and metabolic syndrome
- •Use of psychoactive and investigational medications
- •Subjects with MRI contraindications such as pacemaker, aneurysm clips, artificial heart valves, metal fragments, foreign objects or claustrophobia. All subjects subjects will receive a structural MRI as part of this study. Individuals with evidence of infection, infarction, neoplasm or other lesions will be excluded. Individuals found to have abnormalities in their structural MRI will be referred to their primary physician for further evaluation and management.
- •Special diet regimens such as lactose free or vegan
结局指标
主要结局
Dietary dairy food intake measured using 7-day diet recording
时间窗: 1 week, prior to MRS scan
Cerebral glutathione (GSH) levels measured by magnetic resonance spectroscopy (MRS)
时间窗: Baseline
次要结局
未报告次要终点
研究者
In-Young Choi, Ph.D.
Associate Professor
University of Kansas Medical Center
研究点 (1)
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