Dairy Intake and Cerebral Antioxidant Defense in Aging: a Dietary Intervention Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Change in Glutathione (GSH) levels
研究概览
简要总结
The purpose of this study is to learn if increased dairy food consumption helps brain health in older adults by protecting nerve cells from damage.
详细描述
Eating more dairy foods may improve brain health as people age by increasing the brain's natural defenses to protect nerve cells against chemical stress. Researchers think there may be a relationship between the brain's natural defense system and the amount of dairy food intake. Strengthening these defenses could provide beneficial protection to the brain against neurodegenerative age-related diseases and cognitive decline.
Glutathione (GSH) is a metabolite in the human brain protective system. It plays a key role in protecting cells against oxidative stress, which is one of the major processes contributing to aging and neurodegeneration. Preliminary findings suggest that there may be a correlation between dairy food intake and GSH levels in the aging brain. Magnetic Resonance Spectroscopy (MRS) measures chemicals in the brain. It is a noninvasive measure of the effects of dairy food intake on the major protective metabolite levels in the living human brain in aging.
This study involves using an MRI with special MRS scans to see if adequate dairy food intake may aid in enhancing cerebral protective capacity to fight against age-related disease and cognitive decline in the brain.
Participants will be asked to make a total of six visits to the research site. Participation will last about 3 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Good general health with no concomitant diseases which could interfere with the study
- •Low dairy consumption (≤ 1.5 dairy serving/day)
- •Mini-Mental State Exam (MMSE) ≥ 24
- •body mass index (BMI) range: 18.5 - 35 kg/m2
排除标准
- •Presence of any central neurological diseases or prior major head trauma with loss of consciousness
- •Presence of an active unstable and life-threatening systemic illness (e.g., cancer)
- •Presence of major psychiatric disorders within the past 3 years including depression, anxiety, and alcohol or drug abuse
- •Presence of diabetes mellitus, metabolic syndrome or uncontrolled hypertension
- •Use of psychoactive and investigational medications
- •Subjects with MRI contraindications such as pacemaker, aneurysm clips, artificial heart valves, metal fragments, foreign objects or claustrophobia.
- •Pregnancy
- •Special diet regimens such as lactose free or vegan
结局指标
主要结局
Change in Glutathione (GSH) levels
时间窗: Change from Baseline to Month 3
GSH levels are measured in frontal and parietal regions of the brain using our multiple quantum filtered chemical shift imaging (MQ CSI) technique with a 3 T clinical scanner.
次要结局
未报告次要终点