Comparison of Effect of Intravenous Chlorpheniramine Maleate and Butorphanol as Premedication on Postoperative Agitation in Adult Patients Undergoing Otorhinolaryngeal Surgery.

Agitation with general anesthesia for otorhinolaryngeal surgeries was so frequent reaching up to 55.4%. Chlorpheniramine maleate a first-generation antihistaminic that antagonizes histamine H1-receptor. It is mainly used as an anti-allergic but has some anti-depressant and anti-anxiety actions, with unknown mechanism as well. Butorphanol is commonly used for the management of cancer, post-operative, gynecological, and obstetric pain. The main aim of the study is to compare the post operative agitation in patients receiving preemptive intravenous chlorpheniramine maleate and butorphanol undergoing otorhinolaryngeal surgeries under GA.The present study will be conducted in the department of Anaesthesiology, G.G.S.Medical College & Hospital, Faridkot on 80 patients belonging to ASA grade I & II, aged 18-65 years of either gender scheduled to undergo Otorhinolaryngeal surgeries. Patients will be randomly assigned into 2 equal groups. The first group (C) will receive chlorpheniramine maleate 5mg diluted in 9ml isotonic saline IV 15 minutes preinduction, second group (B) will receive butorphanol 1mg diluted in 9ml isotonic saline 15 minute preinduction.