NCT02377440已完成不适用
Effects of Angiotensin Converting Enzyme Inhibitors (ACEI) on Bone Turnover
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- Change in serum CTX levels in pg/mL
研究概览
简要总结
The investigators hypothesize that older persons (≥45 years) treated with ACEI for HTN control will have: i) improved status of bone turnover (decreased P1NP and CTX), and ii) decreased levels of RANKL and RANKL/OPG, compared to those not treated with ACEI and not using RAS-related medications
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •at least 45 years of age
- •a diagnosis of (either new or uncontrolled) HTN who will need a new medication for HTN control
- •able to consent (no medial issues impairing judgment for consenting based on clinical providers' judgment).
排除标准
- •younger than 45 years of age
- •a diagnosis of metabolic bone disease
- •a diagnosis of osteoporosis or use of medication to treat osteoporosis
- •a diagnosis of diabetes mellitus, or renal insufficiency, or cancer
- •history of allergy to ACEI or ARB, 6) history of use of ACEI or ARB.
结局指标
主要结局
Change in serum CTX levels in pg/mL
时间窗: baseline, 3 months
次要结局
未报告次要终点
研究者
Nahid Rianon
Assistant Professor
The University of Texas Health Science Center, Houston
研究点 (2)
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