ApoE Genotyping Analysis in Patients With Suspected Non-haemorrhagic Amyloid Angiopathy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- ApoE genotypage
研究概览
简要总结
Ischaemic microangiopathic features have recently been incorporated into the criteria for cerebral amyloid angiopathy (CAA).
ApoE genotyping (presence of the E4 allele) is routinely used to help determine the aetiology of a haemorrhagic microangiopathy found on MRI.
Chronic ischaemic disease in CAA is characterised by the presence of :
- multispot pattern on the FLAIR sequence
- severe periventricular FLAIR hypersignals with posterior predominance
The main aim of this study was therefore to analyse the frequency of the presence of one (or two) E4 allele(s) on ApoE genotyping in patients with suspected CAA based on ischaemic MRI involvement with a typical radiological pattern.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with ischaemic stroke (from causes other than CAA, as CAA is not a frequent cause of ischaemic stroke) with associated stigmata of microangiopathy on MRI that may suggest associated CAA.
- •Patients treated at Nîmes University Hospital
排除标准
- •Patient refusing to participate
研究组 & 干预措施
ischaemic microangiopathy
The study is aimed at patients with manifestations related to a vascular accident visible on MRI.
结局指标
主要结局
ApoE genotypage
时间窗: baseline
To analyse the frequency of the presence of one (or two) E4 allele(s) on ApoE genotyping in patients with suspected AAC. Endpoint: presence of the E4 allele (Yes/No).
次要结局
未报告次要终点