Evaluation of the Effect of the Consumption of Papaya, Tomato, and Carrot on the Bioavailability of Carotenoids
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 4
- 主要终点
- Pharmacokinetics of Carotenoid Absorption From Papaya, Carrot and Tomato
研究概览
简要总结
The goal of this study is to determine if papaya fruits are an exceptionally good food source for carotenoids in humans, particularly when compared more common carotenoid sources like carrots and tomatoes. This objective will be accomplished by quantitation of the immediate post-prandial plasma concentrations of parent carotenoids and vitamin A metabolites from subjects who consumed a meal containing fresh papaya, tomato, and carrot.
详细描述
The main purpose of this study is comparing bioavailability of papaya carotenoids versus carrot and tomato carotenoids. Previously, vitamin A deposition in rat livers was studied, showing that carotenoid bioavailability from papaya is higher than from spinach, parsley and carrots. Detailed knowledge about human carotenoid absorption and conversion from papaya fruit compared to other food sources is still lacking.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy individuals
排除标准
- •lactating, pregnant, or planned to be pregnant
- •smokers/those who use tobacco products
- •metabolic or malabsorption disorders
- •had a history of cancer
- •history of liver insufficiency or other gastro-intestinal diseases
- •allergy to papaya, carrots or tomatoes
结局指标
主要结局
Pharmacokinetics of Carotenoid Absorption From Papaya, Carrot and Tomato
时间窗: 8 post-prandial blood samples over 9.5 hours
The primary goal of this research is to investigate whether papaya can deliver increased quantities of carotenoids when compared to carrot and tomato. An area under the curve for concentration of carotenoids (from triglyceride rich lipoprotein (TRL) fraction of plasma) over time will be determined to quantify absorption, after subjects consume a meal containing papaya, carrot or tomato.
次要结局
未报告次要终点
研究者
Jessica Cooperstone
Research Scientist
Ohio State University