Theta Burst Stimulation for motor impairment after stroke

Completed

• Conditions: Topic: Stroke Research Network; Subtopic: Rehabilitation; Disease: Therapy type; Circulatory System; Stroke

• Registration Number: ISRCTN03884521
• Lead Sponsor: niversity College London Hospitals NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04-29
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

1. History of a single ischaemic stroke, initially affecting the hand
2. Minimum interval since stroke onset one year (no upper limit)
3. Residual impairments of hand function (strength and/or dexterity)
4. Some degree of hand movement defined as present wrist extension (>=20%) and ability to grasp
5. Capable of giving informed consent
6. Aged 18 - 80 years, either sex

Exclusion Criteria

1. Intracerebral hemorrhage
2. Large ischaemic lesions involving almost the whole MCA territory
3. Significant tone problems in the hand (greater than 2 in the Ashworth Scale)
4. Severe cognitive impairment defined as mini-mental state examination (MMSE) less than 20
5. Residual aphasia or visual field defect (greater than or equal to 2 in the relative item of the National Institutes of Health Stroke Scale [NIHSS])
6. Past or current history of other neurological or psychiatric disease including epilepsy, previous or recurrent stroke and peripheral neuropathy
7. Major systemic illness
8. Use of anticonvulsant, psychotropic or sedative or medication
9. Excessive use of alcohol or other substances
10. Accepted contraindications for TMS (presence of metal in the head (excluding the mouth), intracardiac lines, cardiac pacemakers)

Study & Design

• Study Type: Interventional
• Study Design: Not specified