Evaluation of Patients With Lupus Nephritis Using Kidney MRI (Magnetic Resonance Imaging)

Not Applicable

Terminated

• Conditions: SLE (Systemic Lupus)
• Interventions: Device: MRI

• Registration Number: NCT06445127
• Lead Sponsor: Johns Hopkins University

Brief Summary

This study is being done to find out if a non-invasive Magnetic Resonance Imaging (MRI) examination of the kidneys may be helpful in patients with systemic lupus erythematosus (SLE).

Detailed Description

The primary objective of this research is to evaluate the best techniques for magnetic resonance imaging (MRI) of the kidneys in patients with lupus nephritis. This research is being done to evaluate a minimally-invasive method for assessing kidney inflammation and kidney damage in patients with lupus nephritis. Both kidneys will be assessed.

Study Timeline

• Study Start: 2024-05-07
• Study First Submitted: 2024-05-13
• Study First Submitted QC: 2024-05-31
• Study First Posted: 2024-06-06
• Primary Completion: 2025-01-01
• Study Completion: 2025-04-08
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-02
• Last Update Posted: 2025-05-07

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Male and female adults over the age of 18 who have been diagnosed with SLE and are able to undergo a kidney MRI.

Exclusion Criteria

• Any patient that has undergone a renal transplant.
• Any patient that is receiving renal dialysis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
MRI	MRI	A participant will undergo a MRI (1-4).

Primary Outcome Measures

Name	Time	Method
Presence of inflammation	Six months	The presence of inflammation within both kidneys will be measured using MRI.
Presence of fibrosis	Six months	The presence of fibrosis within both kidneys will be measured using MRI.

Trial Locations

Locations (1)

Johns Hopkins University School of Medicine; 🇺🇸 Baltimore, Maryland, United States