Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?

Not Applicable

Completed

• Conditions: Major Depressive Disorder; Mood Disorders
• Interventions: Behavioral: Computerized self-help program for depression

• Registration Number: NCT01818453
• Lead Sponsor: University of Texas at Austin

Brief Summary

The goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression. Several studies now indicate that completing an internet-based treatment for depression, called Deprexis, can significantly improve symptoms of depression. However, not everyone improves. The purpose of this study is to determine whether genetic profile can predict who is likely to improve.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-02-20
• Study Start: 2013-03
• Study First Submitted QC: 2013-03-21
• Study First Posted: 2013-03-26
• Status Verified: 2015-11
• Primary Completion: 2015-11
• Study Completion: 2015-11
• Last Update Submitted: 2015-11-06
• Last Update Posted: 2015-11-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• English-speaking
• Have reliable access to the internet (i.e., dialup or broadband access)
• Be willing to donate saliva for DNA research
• Have a current symptoms of depression
• Be stable on medication and/or therapy (i.e. no changes within 2 weeks of study entry)

Exclusion Criteria

• Any diagnosis of a psychotic or bipolar disorder
• Meeting for alcohol/drug dependence in the past year
• Having current suicidal risk warranting crisis intervention

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Computerized self-help program for depression	Computerized self-help program for depression	Participants will have access to a computerized self-help program for depression, called deprexis, for 8 weeks.

Primary Outcome Measures

Name	Time	Method
Quick Inventory of Depressive Symptomatology (Self-Report) (QIDS-SR-16)	Administred every 2 weeks while the participant is engaged in the online deprexis treatment program to measure depression symptom severity.

Secondary Outcome Measures

Name	Time	Method
Inventory of Depression and Anxiety Symptoms (IDAS)	The IDAS will be completed as part of the pre- and post-treatment questionnaires to assess for symptoms of depression and anxiety.
Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ)	The ATRQ will be administered as part of the pre-treatment questionnaires to evaluate psychotropic efficacy.
Hamilton Depression Rating Scale (HAM-D)	The HAM-D will be completed during the pre- and post-treatment phone interviews to assess depression symptom severity.
Psychiatric Diagnostic Screening Questionnaire (PDSQ)	The PDSQ will be completed as part of the pre- and post-treatment questionnaires to screen for the most common DSM-IV Axis I disorders..
Risky Families Questionnaire (RFQ)	The RFQ will be completed as part of the pre-treatment questionnaires to assess early familial experiences and the harshness of family climate.
Sheehan Disability Scale (SDS)	The SDS will be completed as part of the pre- and post-treatment questionnaires to evaluate symptom-related disability.

Trial Locations

Locations (1)

The University of Texas at Austin; 🇺🇸 Austin, Texas, United States