NCT04725019
Not yet recruiting
Not Applicable
Enhancing Motor Learning in Children With Cerebral Palsy Using Transcranial Direct-current Stimulation
Boston University Charles River Campus0 sites60 target enrollmentAugust 1, 2021
ConditionsCerebral Palsy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cerebral Palsy
- Sponsor
- Boston University Charles River Campus
- Enrollment
- 60
- Primary Endpoint
- Changes in the Box and Blocks test
- Status
- Not yet recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
The goal of this study is to test the effects of transcranial direct current stimulation (tDCS) on motor learning and brain plasticity in children with unilateral spastic cerebral palsy (USCP).
Investigators
Claudio
Assistant Professor
Boston University Charles River Campus
Eligibility Criteria
Inclusion Criteria
- •Children between 6-17 years old who have been diagnosed with cerebral palsy, with the following joint mobility: wrist extension 20º, metacarpophalangeal and proximal interphalangeal joints 10º. Ability to cooperate and follow simple directions.
Exclusion Criteria
- •Seizure beyond age 2, use of anti-seizure medication, history or family history of epilepsy, cranial metal implants, structural brain lesion, devices that may be affected by tDCS or TMS (pacemaker, medication pump, cochlear implant, implanted brain stimulator)
- •True positive response on the Transcranial Magnetic Stimulation and MRI Safety Screen
- •Current use of medications known to lower the seizure threshold
- •Previous episode of unprovoked neurocardiogenic syncope
- •Indwelling metal or incompatible medical devices
- •Centrally-acting medications including anti-seizure medications
- •Evidence of scalp disease or skin abnormalities
- •Current medical illness unrelated to CP
- •High motor ability in affected arm (i.e. no asymmetry in scores of hand function)
- •Severe spasticity
Outcomes
Primary Outcomes
Changes in the Box and Blocks test
Time Frame: Day before intervention begins, compared to day after intervention ends (approximately 1 week)
Investigators will measure changes in the movement speed of the hands.
Changes in the Assisting Hand Assessment
Time Frame: Day before intervention begins, compared to day after intervention ends (approximately 1 week)
Investigators will measure changes in how well the child uses both hands cooperatively for bimanual activities.
Secondary Outcomes
- Changes in Motor-evoked Potential assessment(Day before intervention begins, compared to day after intervention ends (approximately 1 week))
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