PREVER Study: Efficacy of Chlorthalidone associated with Amiloride versus Losartan in reducing blood pressure of patients with hypertension Prever 2 Study
Phase 3
Recruiting
- Conditions
- Hypertension
- Registration Number
- RBR-4s7gh3
- Lead Sponsor
- Hospital de Clínicas de Porto Alegre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
I. Individuals with 40 to 70 years, of both sexes;
II. Diagnosis of Hypertension in stage I, ie, systolic (SBP) between 140-159 mmHg or diastolic blood pressure (DBP) between 90-99 mmHg
Exclusion Criteria
I. Chronic diseases that reduce life expectancy or difficulty in understanding the guidelines, which limit the possibility of participation in the study;
II. Refusal to participate or sign an informed consent;
III. Pregnancy or women most likely to become pregnant during the study;
IV. Known allergy to any of the study drugs;
V. Prior diagnosis of secondary hypertension ;
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method I. Lowering blood pressure to less than 140/90 mmHg;<br>II. Incidence of Adverse Events;<br>III. Incidence of diabetes mellitus, microalbuminuria, hypokalemia, hiperuricemia and left ventricular hypertrophy on ECG.<br>
- Secondary Outcome Measures
Name Time Method I. All-cause mortality<br>II. Incidence of Coronary Artery Disease (Acute Coronary Syndrome, need for revascularization, sudden death)<br>III. Fatal and nonfatal stroke<br>IV. Heart failure (requiring hospitalization)<br>V. Duplication of plasma levels of creatinine or need for dialysis<br>VI. Incidence of diabetes mellitus.<br>