NCT03965637已完成3 期
Effect of Ascorbic Acid Administration on Intraoperative Blood Loss and Wound Healing in Total Abdominal Hysterectomy
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- volume of hemorrhage
研究概览
简要总结
vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.
详细描述
In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day before surgery and during surgery in patients who undergo abdominal hysterectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •To be 18 years and older
- •No smoking
- •No history of bleeding disorder
- •No history of favism
- •No history of uterus, ovary, cervical cancer
排除标准
- •Need to injection of vasopressor drugs
- •Surgeon disagreement
研究组 & 干预措施
vitamin C
Experimental
Intervention patients will be received double dose of Ascorbic acid via intravenous injection
干预措施: vitamin C (Drug)
结局指标
主要结局
volume of hemorrhage
时间窗: During surgery
volume of hemorrhage during surgery
次要结局
- Hemoglobin value(6 and 24 hours after surgery)
- wound healing(during 2 weeks post surgery)
- duration of stay in hospital(up to 2 weeks post surgery)
- Infection(up to 2 weeks post surgery)
研究者
Zahra Vahdat Shariatpanahi
Associate Professor
Shahid Beheshti University
研究点 (1)
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