Impact of Ascorbic Acid on Post-Cardiothoracic Surgery Inflammation
- Registration Number
- NCT00519337
- Lead Sponsor
- Hartford Hospital
- Brief Summary
The purpose of this study is to see if ascorbic acid (Vitamin-C) therapy will reduce inflammation following heart surgery.
- Detailed Description
Atrial Fibrillation is a significant cause of morbidity following cardiothoracic surgery. Despite prophylactic therapy with beta-blockers and amiodarone, post-operative atrial fibrillation occurs in approximately 22% of patients. We believe that by reducing the inflammation that is caused during CTS, we can see further improvements without any negative effects on hemodynamics. Ascorbic acid, a free radical scavenger has been found to lower inflammation mediators but never in a CTS population. This study will help determine the affect of ascorbic acid on the inflammation associated with CTS.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
- Cardiothoracic surgery
- Pregnancy
- Prior hypersensitivity to ascorbic acid
- Renal Calculi
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 Placebo Identical placebo 1 Ascorbic acid Ascorbic acid
- Primary Outcome Measures
Name Time Method In CTS patients receiving standard of care therapy,evaluate the effect of ascorbic acid therapy on c-reactive protein (CRP) concentration on post-CTS day 3 and the total post-CTS systemic exposure to CRP over 4 days. 4 Postoperative Days
- Secondary Outcome Measures
Name Time Method Evaluate the effect of high intensity versus low intensity statin therapy on blood concentrations of fibrinogen, and White blood cell count on post-CTS days 3 and the total post-CTS systemic exposure to these biomarkers over 4 days. 4 Postoperative Days
Trial Locations
- Locations (1)
Hartford Hosptial
🇺🇸Hartford, Connecticut, United States