Intravenous Ascorbic Acid Administration in Hysterectomy

Phase 3

Completed

• Conditions: Abdominal Hysterectomy
• Interventions: Drug: vitamin C

• Registration Number: NCT03965637
• Lead Sponsor: Shahid Beheshti University

Brief Summary

vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.

Detailed Description

In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day before surgery and during surgery in patients who undergo abdominal hysterectomy.

Study Timeline

• Study First Submitted: 2019-05-26
• Study First Submitted QC: 2019-05-26
• Study First Posted: 2019-05-29
• Study Start: 2019-08-23
• Primary Completion: 2020-01-30
• Study Completion: 2020-01-30
• Status Verified: 2020-04
• Last Update Submitted: 2020-04-29
• Last Update Posted: 2020-05-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• To be 18 years and older
• No smoking
• No history of bleeding disorder
• No history of favism
• No history of uterus, ovary, cervical cancer

Exclusion Criteria

• Need to injection of vasopressor drugs
• Surgeon disagreement

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
vitamin C	vitamin C	Intervention patients will be received double dose of Ascorbic acid via intravenous injection

Primary Outcome Measures

Name	Time	Method
volume of hemorrhage	During surgery	volume of hemorrhage during surgery

Secondary Outcome Measures

Name	Time	Method
Hemoglobin value	6 and 24 hours after surgery	Hemoglobin value after surgery
wound healing	during 2 weeks post surgery	complications after surgery
duration of stay in hospital	up to 2 weeks post surgery	Length of stay in hospital
Infection	up to 2 weeks post surgery	Developing infection up to 2 weeks

Trial Locations

Locations (1)

Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences; 🇮🇷 Tehran, Iran, Islamic Republic of