Role of Mega Dose of Vitamin C in Critical COVID-19 Patients
- Registration Number
- NCT04682574
- Lead Sponsor
- University of Lahore
- Brief Summary
Vitamin C (ascorbic acid) is a water-soluble vitamin having anti-inflammatory, immunomodulatory, anti-oxidative, antithrombotic and antiviral properties. Considering these effects vitamin C should have beneficial impact in patients suffering from sepsis and acute respiratory distress syndrome (ARDS). The current study is designed to assess the beneficial effects of Vitamin C in COVID-19 infected patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 278
critically ill patients admitted in ICU
allergic to Vitamin C didnt given the consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description vitamin C Vitamin C The dose would be 30 grams a day (10 grams TDS) for 3 days with standard treatment
- Primary Outcome Measures
Name Time Method Partial pressure of Oxygen in arterial blood to fraction of inspired Oxygen (P/F ratio) 1 and 4th day Survival analysis 28 days follow up
- Secondary Outcome Measures
Name Time Method Length of Hospital stay Admission to discharge Need for intubation 28 days number of intubations needed in both groups.
Inflammatory markers before the start of treatment (day 1) and on day 4 comparison of the inflammatory markers, CRP, D.Dimer, Procalcitonin, LDH, TLC and hematological variables at day four after the intervention started.
APACHE II score before the start of treatment (day 1) and on day 4
Trial Locations
- Locations (1)
Bahria Town International Hospital
🇵🇰Lahore, Punjab, Pakistan