A pathophysiological study in diabetes-related dementia
Not Applicable
Recruiting
- Conditions
- Dementia associated with dementia
- Registration Number
- JPRN-UMIN000034032
- Lead Sponsor
- Tokyo Medical University Department of Geriatric Medicine
- Brief Summary
We studied amyloid (PiB) PET in 31 patients with cognitive impairment and dementia associated with type 2 diabetes mellitus, including 16 with Alzheimer disease (AD), 10 with mild cognitive impairment (MCI), and 5 with other types of dementia. Our PET study showed that 63% (10/16) of patients with AD, 40% (4/10) of patients with MCI, and 40% (2/5) of patients with other types of dementia showed amyloid positivity. Our results suggest that there are subgroups with neuronal damage independent of amyloid pathology among patients with clinically diagnosed AD associated with DM.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Not provided
Exclusion Criteria
Severe dementia
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Amyloid and tau accumulation on PET
- Secondary Outcome Measures
Name Time Method Amyloid and tau measurements in cerebrospinal fluid