The Effect on Muscle Architecture Properties and Motor Functions of Aerobic Training in Children With Duchenne Muscle Dystrophy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Duchenne Muscular Dystrophy
- Sponsor
- Hacettepe University
- Enrollment
- 19
- Locations
- 1
- Primary Endpoint
- Evaluation of Muscle Thickness, Fascicle Length, Pennation Angle with Ultrasonography
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Duchenne Muscular Dystrophy (DMD) is the most common neuromuscular disease in childhood with an estimate incidence of 1 in 3500 to 5000 male births. The effect of aerobic training on muscle architectural properties and motor functions such as muscle activation is not clear in DMD. The aim of this study is to investigate the effects of aerobic training on these parameters in children with DMD. Twenty children with DMD included in the study will be divided into two groups as home program and home program+aerobic training with block randomization method. Home program including stretching, respiratory, range of motion and mild resistance exercise with body weight will be asked to apply 3-5 days a week for 12 weeks, aerobic training will be performed 3 days a week for 12 weeks at 60% of their maximum hearth rate with 50 minutes total duration consisting of 10 min warm up and 10 min cool down period. Muscle architectural properties, muscle strength, muscle activation and motor function will be assessed with ultrasonographic, hand-held myometry, surface EMG and Motor Function Measure, consecutively. Assessments will be applied at pre-training and after 12 weeks of training.
Investigators
Numan Bulut
Research Assistant
Hacettepe University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Evaluation of Muscle Thickness, Fascicle Length, Pennation Angle with Ultrasonography
Time Frame: 10 minutes
Bilateral Vastus Lateralis and Medial Gastrocnemius US evaluations were performed with use of a 5-10 MHz linear probe (Diasus Dynamic Imaging Ltd, Livingston, Scotland,UK). Children were positioned supine with their legs extended and their muscles relaxed for vastus lateralis.Children were positioned prone position with their legs and their muscles relaxed for medial gastrocnemius. While Muscle Thickness and Fascicle Length would be expressed as centimeters, pennation angle would be angularly indicated.
Secondary Outcomes
- Assessment of Motor Function by Motor Function Measure (MFM)(30 minutes)
- Evaluation Motor Performance with Timed Functional Test and Six minute walk test(20 minutes)
- Shortening assessment of trunk and lower extremity muscles with goniometric measurement and tape(20 minutes)