Determining Biomechanical and Morphological Factors That Affect Children With Duchenne Muscular Dystrophy (DMD) Who Loss of the Ability to Walk
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Duchenne Dystrophy Muscular
- Sponsor
- University Hospital, Brest
- Enrollment
- 50
- Locations
- 5
- Primary Endpoint
- Determine biomechanical and morphological predictive factors of the loss of the walk ability of the children with DMD
- Last Updated
- 8 years ago
Overview
Brief Summary
The loss of ability to walk in many children with DMD (Duchenne muscular Dystrophy) is a pejorative event. Biomechanical and morphological unknowledge about the loss of the walk ability in children with DMD is an obstacle in reeducative, pharmacological or surgical therapeutic targets.
Detailed Description
The loss of ability to walk in many children with DMD (Duchenne muscular Dystrophy) is a pejorative event. Biomechanical and morphological unknowledge about the loss of the walk ability in children with DMD is an obstacle in reeducative, pharmacological or surgical therapeutic targets. We suppose that there are muscular characteristics and predictive parameters of the loss of walk ability. The identification of these potential therapeutic targets would improve the surveillance and the clinical care but would also guide future clinical and fundamental trials too.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Young man ou woman (5 to 17 years old) with Duchenne Muscular Dystrophy (confirmed by immunohistochimy on the muscular biopsy and/or mutation in the dystrophin confirmed by molecular biology)
- •Time more than 7 secondes to test of 10 m and/or distance less than 330 m to walk test of 6 minutes. These values are recent markers to include children with a strong risk of loss of walking ability in 2 years.
- •Parental inform sign consent and / or child inform consent
Exclusion Criteria
- •Recent orthopaedic surgery of lower limbs (6 months)
- •Other chronic disease associated, which have an impact on the walking
- •Cognitive Deficiency or behavior disorders limiting the understanding of the study
- •Children who can benefit ATU (translarna ® or other) during the study
- •All MRI contradications : pacemaker or neurosensory stimulator or implantable defibrillator, neurosurgical valves, cochlear implant or ferromagnetic implants near nervous structures, brace, metallic prostheses, not cooperative or agitated patients, patient claustrophobic, pregnant woman.
Outcomes
Primary Outcomes
Determine biomechanical and morphological predictive factors of the loss of the walk ability of the children with DMD
Time Frame: 24 years
Determine the biomechanical factors (muscular atrophy, muscular strength, muscular shrinkage) and morphological (greasy infiltration, contractile portion, muscular geometry) predictive of the loss of the walk ability of the children with DMD
Secondary Outcomes
- Identify the muscles wasting and their implication in the loss of strength and the walking ability(24 years)
- Biomechanical evolutionary data collected during the last 2 years of walking(24 years)
- Establish the relationship between the parameters of walking and the scrawny body morphological anomalies(24 years)