Postprandial Profiles of Metabolites and Appetite-regulating Hormones in Plasma and Cerebrospinal Fluid
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Appetite regulating hormones measured by specific immunoassays
研究概览
简要总结
Overweight and obesity are rising in prevalence and becoming a growing threat to public health. Obesity is associated with an increased all-cause mortality, impaired quality of life, and numerous of disorders. Therapeutic strategies against obesity - which include an abundance of dietary and physical training programmes and pharmaceutical drugs to increase energy expenditure or limit appetite or gastro-intestinal fat absorption - have shown limited success on long term weight loss. Thus, overweight and associated conditions is becoming the new normal and there is a need for better understanding gut-to-brain signalling, hormonal and metabolic disturbances in overweight individuals.
The purpose of this health science research project is to describe the coinciding plasma and cerebrospinal fluid (CSF) profiles of selected biomarkers after co-ingestion of a meal and model pharmaceuticals in patients with overweight and/or type 2 diabetes compared to healthy control individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •10 male patients with obesity (BMI >30) and type 2 diabetes
- •10 male volunteers with normal weight (BMI 20-24) matched by age
- •10 male volunteers with obesity (BMI >30) matched by age
排除标准
- •Unwillingness to participate or wish to withdraw from ongoing protocol
- •Hepatic disease or hemorrhagic diatheses (including abnormal International Normalized Ratio (INR), bilirubin, blood levels of thrombocytes, alanine-aminotransferase (ALAT))
- •Anticoagulant treatment (e.g. treatment with warfarin, apixaban or another oral anticoagulant)
- •Anaemia (p-hemoglobin below normal range)
- •Nephropathy (se-creatinine >130 μM and/or albuminuria)
- •Suspected difficult access to the spinal canal (e.g. pronounced scoliosis, spinal stenosis, osteoporotic coincidence in the lower back, spina bifida, meningocele after surgical intervention)
- •Lumbar skin infection (e.g. herpes zoster, pustules or ulcers)
- •Medical history with headaches - both in connection with dura puncture and frequent headaches of other types
- •Central nervous system disease (including dementia, previous stroke, multiple sclerosis, epilepsy, etc.)
- •Clinical suspicion of increased intracranial pressure (headaches, visual disturbances etc.)
- •Patients with type 2 diabetes: Treatment with DPP-4 inhibitor or GLP-1 receptor agonist. Late diabetic complications including proliferative diabetic retinopathy (anamnestic), arteriosclerotic cardiovascular disease (heart failure or previous ischemic event/myocardial infarction)
结局指标
主要结局
Appetite regulating hormones measured by specific immunoassays
时间窗: After 4 hours
次要结局
未报告次要终点
研究者
Mikkel Bring Christensen
Chief consultent at the department of Clinical Pharmacology
Bispebjerg Hospital