Appetite Regulation by Human Chemosignals From Tears and Plasma

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Biological: Sniffing trickled saline; Biological: Sniffing emotional tears; Biological: Sniffing fasting plasma; Biological: Sniffing postprandial plasma

• Registration Number: NCT01389869
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Obesity is closely related to metabolic diseases and its prevalence is sharply increasing. However, there is no safe and effective treatment for obesity so far, the investigators need a breakthrough idea to curtail the constant threat of obesity. It has been recently demonstrated that emotional tears of women can modify sexual responses, one of basic instincts, in men. As appetite and food intake is another basic instinct, chemosignals from tears and plasma may modify appetite and eating behavior in humans.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2011-06
• Study First Submitted: 2011-07-06
• Study First Submitted QC: 2011-07-07
• Study First Posted: 2011-07-08
• Primary Completion: 2011-12
• Study Completion: 2012-01
• Status Verified: 2013-12
• Last Update Submitted: 2013-12-05
• Last Update Posted: 2013-12-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• Woman: Negative for HIV, Syphilis (VDRL), and Hepatitis B and C
• Man: Has a body mass index (BMI) of 18.5 kg/m2 to 27 kg/m2, inclusive.

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Exclusion Criteria

• Woman: Has eyelids inflammation, conjunctivitis, keratitis, lacrimal duct obstruction. Has skin diseases around eyes.
• Man: Has diabetes mellitus or dyslipidemia on medication. Received gastrointestinal surgery except appendectomy and hemorrhoidectomy.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Saline	Sniffing trickled saline	Saline collected after being trickled down women's skin below eyes like tears
Tears	Sniffing emotional tears	Emotional tears of female volunteers while watching sad video clips
Fasting	Sniffing fasting plasma	Their own overnight fasting plasma of male volunteers
Prandial	Sniffing postprandial plasma	Their own postprandial plasma of male volunteers

Primary Outcome Measures

Name	Time	Method
The degree of appetite by visual analogue scale (VAS) and the amount of food intake by standard test meals in male volunteers while sniffing tears, trickled saline (control), and postprandial and fasting plasma in random order.	Visual analogue scale (VAS) will be rated 10 minutes after initial sniffing of tears/plasma just before eating standard test meals. The amount of food intake will be measured by weighing the meals before and after eating.

Secondary Outcome Measures

Name	Time	Method
Appetite regulating hormones(ghrelin, GLP-1, PYY), glucose, testosterone. Determination of tears, tickled saline, and plasma.	Blood samples for measuring appetite regulating hormones, glucose, testosterone will be collected at -10, 0, and 60 min.

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of