Skin resident T cells in atopic dermatitis and psoriasis - Escape from regulation?
Completed
- Conditions
- atopic dermatitiseczema1000170810014982
- Registration Number
- NL-OMON31571
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
- adult (18-70 years of age), male or female patients diagnosed with atopic dermatitis (diagnostic criteria as described by Williams), or (guttate or plaque) psoriasis
- biopsy location (about 2x2 cm) should not be treated with topical steroids for at least 1 week
Exclusion Criteria
- use of systemic immunosuppressive drugs (i.e., cyclosporin, prednisolone, methotrexate, neotigason, fumaric acid) in the 6 weeks prior to the inclusion
- exposure of biopsy location to (extraordinary) UV sunlight (i.e. UV-therapy, sunny holiday) in the 6 weeks prior to inclusion
- (secondary) skin infection
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>(a) Differences between the suppressive potential of skin resident regulatory T<br /><br>cells isolated from atopic dermatitis, psoriasis patients and healthy control<br /><br>subjects<br /><br>(b) Differences between the the frequency of regulatory T cells in the skin of<br /><br>patients with atopic dermatitis, psoriasis and healthy control subjects.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>