Metabolomics in Occupational Asthma
- Conditions
- Asthma, Occupational
- Interventions
- Device: Breath Biopsy
- Registration Number
- NCT04301674
- Lead Sponsor
- Oslo University Hospital
- Brief Summary
The project aims to increase the diagnostic accuracy in occupational asthma (OA), with emphasis on Irritant Induced Asthma (IIA). Currently, most patients are evaluated in occupational medicine by comparing the exposure and symptom characteristics with epidemiological data. Biological markers may be present in AA, but presently not in IIA. The majority of cases evaluated are considered as possible IIA, i.e. low-dose multiple exposures. VOC features will be analyzed with the Breath Biopsy® and TD-GS-MS (Owlstone Medical Ltd, UK).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
- capable of informed consent.
- asthma diagnosis established by lung specialist or healthy control.
- skin allergy towards plastics or rubber.
- immunocompromised by oral medication.
- contagious respiratory disease.
- biopsy of lung parenchyma within the last 36 hours.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Respiratory Healthy Control Breath Biopsy Employees at Oslo University Hospital Occupational Asthma Breath Biopsy Patients refered for assesment of occupational asthma
- Primary Outcome Measures
Name Time Method Discovery of VOC Biomarkers in Asthma Baseline To evaluate the sensitivity, specificity, positive and negative predictive value of VOC biomarkers in exhaled breath samples to identify asthma.
Discovery of VOC Biomarkers in Occupational Irritant Asthma Baseline To evaluate the sensitivity, specificity, positive and negative predictive value of VOC biomarkers in exhaled breath samples to identify irritant asthma after occupational exposures.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Oslo University Hospital
🇳🇴Oslo, Norway