Effects of Breathing Patterns on Post-prandial Vascular Function

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Behavioral: Normal physiologic rate breathing; Behavioral: Slow breathing

• Registration Number: NCT04864184
• Lead Sponsor: Texas State University

Brief Summary

The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-01
• Study First Submitted: 2021-03-29
• Study First Submitted QC: 2021-04-23
• Study First Posted: 2021-04-28
• Primary Completion: 2021-09-30
• Study Completion: 2021-09-30
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-08
• Last Update Posted: 2021-11-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 21

Inclusion Criteria

• Male participants ages 18-35 years

Exclusion Criteria

• Infection within the previous 4 weeks
• Renal disorders
• Any cardiovascular disorders such as prior myocardial infarction, known coronary artery disease, personal history of stroke, heart failure, cardiac arrhythmias
• Chronic obstructive pulmonary disease
• Diabetes
• Inflammatory bowel disease
• HIV, rheumatoid arthritis, chronic or other inflammatory conditions
• Currently taking steroids or other anti-inflammatory medications
• Current use of nonsteroidal anti-inflammatory drugs
• Smoking
• Stage 2 hypertension or higher (systolic BP of 140 mm Hg or higher and/or diastolic BP of 90 mm Hg or higher)
• Lactose intolerance

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Breathing intervention	Slow breathing	Participants will complete 2-minute breathing exercises following the Breathing App every 15 minutes during a 4-hour postprandial period following high-fat meal consumption.
Breathing intervention	Normal physiologic rate breathing	Participants will complete 2-minute breathing exercises following the Breathing App every 15 minutes during a 4-hour postprandial period following high-fat meal consumption.

Primary Outcome Measures

Name	Time	Method
Changes in oxidative stress	Once at baseline and again at 1, 2, and 4 hours post high-fat meal consumption.	Blood draws will be performed and samples will be processed and stored for future biochemical analysis of blood markers indicative of oxidative stress.
Change in flow-mediated dilation	At baseline and at again 1, 2, 4 hours post high-fat meal consumption	Ultrasound-derived images of the brachial artery pre- and post-suprasystolic cuff inflation will yield flow-mediated dilation values. These are indices are endothelium-dependent vasodilation.

Trial Locations

Locations (1)

Cardiovascular Physiology Laboratory-Texas State University; 🇺🇸 San Marcos, Texas, United States