The Effects of Different Breathing Styles on Post High-Fat Meal Blood Vessel Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Changes in oxidative stress
研究概览
简要总结
The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
盲法说明
Participants will be blinded to the respiratory rates being practiced during each study visit. Breathing patterns will be completed in random order.
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male participants ages 18-35 years
排除标准
- •Infection within the previous 4 weeks
- •Renal disorders
- •Any cardiovascular disorders such as prior myocardial infarction, known coronary artery disease, personal history of stroke, heart failure, cardiac arrhythmias
- •Chronic obstructive pulmonary disease
- •Inflammatory bowel disease
- •HIV, rheumatoid arthritis, chronic or other inflammatory conditions
- •Currently taking steroids or other anti-inflammatory medications
- •Current use of nonsteroidal anti-inflammatory drugs
- •Stage 2 hypertension or higher (systolic BP of 140 mm Hg or higher and/or diastolic BP of 90 mm Hg or higher)
- •Lactose intolerance
研究组 & 干预措施
Breathing intervention
Participants will complete 2-minute breathing exercises following the Breathing App every 15 minutes during a 4-hour postprandial period following high-fat meal consumption.
干预措施: Normal physiologic rate breathing (Behavioral)
Breathing intervention
Participants will complete 2-minute breathing exercises following the Breathing App every 15 minutes during a 4-hour postprandial period following high-fat meal consumption.
干预措施: Slow breathing (Behavioral)
结局指标
主要结局
Changes in oxidative stress
时间窗: Once at baseline and again at 1, 2, and 4 hours post high-fat meal consumption.
Blood draws will be performed and samples will be processed and stored for future biochemical analysis of blood markers indicative of oxidative stress.
Change in flow-mediated dilation
时间窗: At baseline and at again 1, 2, 4 hours post high-fat meal consumption
Ultrasound-derived images of the brachial artery pre- and post-suprasystolic cuff inflation will yield flow-mediated dilation values. These are indices are endothelium-dependent vasodilation.
次要结局
未报告次要终点