Comparative study to evaluate the proteomic and metabolic profile of blood serum in cancer patients belonging to two different nutritional groups
Not Applicable
- Conditions
- Health Condition 1: D498- Neoplasm of unspecified behavior of other specified sites
- Registration Number
- CTRI/2019/09/021015
- Lead Sponsor
- Tata Memorial Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Histologically or cytologically confirmed
Diagnosis of a solid tumour
Aged 1-10 years
Patient should be treatment naïve.
Patients in whom chemotherapy is indicated
Exclusion Criteria
Patients who are on nutritional supplements before first blood collection
Patients with active infection, uncontrolled diabetes, receiving glucocorticoid therapy, or having esophageal-gastrointestinal obstructions responsible for feeding limitations.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To investigate the differences in metabolomic and proteomic markers in peripheral blood of cancer patients <br/ ><br>belonging to different nutritional statusTimepoint: The study will be conducted at two time-points : Time point 1 is at at diagnosis , and Time point 2 is 3 months <br/ ><br>from diagnosis.
- Secondary Outcome Measures
Name Time Method Validate the animal model of malnutrition being developed in our lab by comparing its proteome <br/ ><br>and metabolome against the profiles observed in malnourished cancer patients <br/ ><br>Change in the proteomic and metabolomics profile of cancer patients belonging to different <br/ ><br>nutritional groups over a period of timeTimepoint: The study will be conducted at two time-points : Time point 1 is at diagnosis , and Time point 2 is 3 months <br/ ><br>from diagnosis.