Long-term Follow-up of Living Liver Donors: A Single-center Experience

Completed

• Conditions: Liver Transplantation
• Interventions: Other: health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).

• Registration Number: NCT04814290
• Lead Sponsor: Mansoura University

Brief Summary

Data on the long-term consequences of living liver donation are scarce. This study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (HRQoL) in 237 living liver donors and 239 matched controls during 48 to 168 months of postdonation follow-up.

Detailed Description

Data on the long-term consequences of living liver donation are scarce. This study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (HRQoL) in 237 living liver donors and 239 matched controls during 48 to 168 months of postdonation follow-up.

We used the 36-item short-form health survey (short form-36 health survey, version 1 \[SF-36\]). The scores for the 4 following subscales were higher in nondonors than in donors: physical functioning (P = 0.009), role limitations due to physical health (P = 0.002), energy/fatigue (P \< 0.001), and bodily pain (P \< 0.001). The scores on the 8 subscales of the SF-36 were higher in donors with living recipients than in donors whose recipients died (P \< 0.001). Our results suggest that living donor right hepatectomy is safe and results in a postdonation HRQoL similar to that of nondonors in those donors whose recipients are healthy, while donors whose recipients die have a lower HRQoL that is significantly negatively correlated with the time since recipient death and improves over time.

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Study Start: 2004-05-01
• Primary Completion: 2014-05-01
• Study Completion: 2021-01-01
• Status Verified: 2021-03
• Study First Submitted: 2021-03-22
• Study First Submitted QC: 2021-03-22
• Last Update Submitted: 2021-03-22
• Study First Posted: 2021-03-24
• Last Update Posted: 2021-03-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 476

Inclusion Criteria

• age 18-50 years
• no comorbidities.
• BMI less than 30 kg/m2.
• compatible ABO group.

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Exclusion Criteria

• Older than 50 years.
• Associated comorbidities.
• Obesity.
• Noncompatible ABO group.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
living liver donors	health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).	cases already underwent hepatectomy for living-donor liver transplantation.
matched controls	health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).	healthy persons who attended the preoperative clinic while preparing for donation but were rejected because of an ABO blood group mismatch.

Primary Outcome Measures

Name	Time	Method
health-related quality of life (HRQoL)	4 to 16 years of follow up	health-related quality of life (HRQoL) (36-item short-form health survey, version 1 \[SF-36\]).