Validity of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma
- Conditions
- Cough Variant Asthma
- Registration Number
- NCT03573284
- Lead Sponsor
- Zhujiang Hospital
- Brief Summary
The aim of the research is to evaluate the clinical value of fractional exhaled nitric oxide(FeNO) ,impulse oscillometry(IOS) and mid-expiratory flow (MEF) in patients with cough variant asthma.
- Detailed Description
The present study has the following objectives:
to evaluate the relationship between BHR and mid-expiratory flow, to assess the diagnostic accuracy of fractional exhaled nitric oxide，impulse oscillometry and mid-expiratory flow in CVA with special regard to its discriminating value between CVA and other causes of a chronic cough, to estimate prognostic value of BHR and fractional exhaled nitric oxide (FeNO) count in predicting response to asthma treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 146
age 18-65 years old. Cough as the sole or predominant symptom lasting for at least 8 weeks, with no radiographic evidence of lung diseases.
treatment of any oral corticosteroid in the last 4 weeks, and respiratory tract infection within 8 weeks.
smoking (min. 6 months) had asthma or other lung diseases, including obliterative bronchiolitis, bronchiectasis,and cystic fibrosis.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method the value of fractional exhaled nitric oxide(FeNO) in patients with cough variant asthma at least 4 weeks of treatment FENO will be performed by using a hand-held portable machine (NIOX MINO, Aerocrine AB, Solna, Sweden) at a standard flow rate of 50 mL/s, in accordance with ATS/ERS recommendations.
the value of impulse oscillometry(IOS) in patients with cough variant asthma at least 4 weeks of treatment R5-R20（respiratory resistance）is measure by Jaeger MasterScreen Pulmonary
- Secondary Outcome Measures
Name Time Method the value of forced mid-expiratory flow (MMEF) in patients with cough variant asthma at least 4 weeks of treatment MMEF will be performed with a spirometer (Jaeger, Hoechberg, Germany) in accordance with the specifications and performance criteria recommended in the American Thoracic Society (ATS)/European Respiratory Society (ERS) Standardization of Spirometry
the value of BHR and fractional exhaled nitric oxide (FeNO) count in predicting response to asthma treatment at least 4 weeks of treatment MCH bronchial provocation tests will be performed with the Jaeger APS Pro system.Provocative dose causing a 20% fall in FEV1(PD20) will be recorded, and BHR is defined as present if PD20≤0.48 mg. FENO is measure by a hand-held portable machine(NIOX MINO, Aerocrine AB, Solna, Sweden)
the relationship between BHR and mid-expiratory flow at least 4 weeks of treatment BHR is measure by Jaeger APS Pro system.MMEF will be performed with a spirometer (Jaeger, Hoechberg, Germany)
Trial Locations
- Locations (1)
Huapeng Yu
🇨🇳Guangzhou, Guangdong, China
Huapeng Yu🇨🇳Guangzhou, Guangdong, China