Comparative evaluation of conventional guided tissue regeneration to albumin-platelet rich fibrin block for the management of intrabony defects via modified-minimally invasive surgical technique:A clinicoradiographic study
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Percentage changes in defect fill, alveolar crest ,defect width, defect angle
研究概览
简要总结
The main objective of periodontal regeneration is to encourage the formation of new bone and create a new cementum with the periodontal ligament (PDL) fiber connected to the alveolar bone. The process of restoring periodontal tissue by utilizing a membrane that acts as an occlusive barrier between PDL tissue and gingival and alveolar bone. GTR is thought to be the ideal approach for preventing the migration of connective and epithelial tissues through the site of surgery.Platelet-rich fibrin (PRF), an autologous platelet concentrate contains several growth factors that are essential for better wound healing. The success of autologous platelet concentrates in some surgical operations may be hampered by restrictions in fibrin mesh in vivo lifetime, despite the fact that different regimens are designed for particular therapeutic applications. A method for creating albumin-enriched platelet-rich fibrin was developed to overcome this restriction.
As far as we are aware, till date no study has been done to compare and assess the clinical and radiographic aspects of conventional GTR against Alb-PRF block using M-MIST technique in the management of intraosseous discrepancies in the periodontal region in patients with localized stage III grade B periodontitis
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 25.00 Year(s) 至 55.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Systemically healthy subjects who are not disqualified for periodontal surgery.
- •2.Subjects with good oral hygiene.
- •Site specific:
- •Individuals with radiographic evidence of bone defect (2 wall/3 wall/Grade II furcation involvement) and localized Stage III Grade B periodontitis.
- •In addition to having an intrabony 2 or 3wall defect of 4–7 mm, subjects should have a clinical attachment level and probing depth more than 4 mm.
排除标准
- •1.Individuals who smoke more than ten cigarettes a day as a chronic smoker.
- •Individuals who are unavailable for additional testing.
- •Pregnant and nursing mothers as subjects.
- •Participants who, within the previous six months, had received any kind of surgical periodontal therapy.
结局指标
主要结局
Percentage changes in defect fill, alveolar crest ,defect width, defect angle
时间窗: at baseline and 4 months after surgery
次要结局
- Plaque Index, Gingival Index, probing depth of the pocket, clinical attachment level(at baseline and 4 months after surgery)
研究者
Bhoomika K V
Bapuji Dental college and Hospital