The Utility of Plasma Free Cortisol in the Assessment of Adrenal Function in Patients with Pituitary Disease
Not Applicable
Completed
- Conditions
- Adrenal functionMetabolic and Endocrine - Other metabolic disorders
- Registration Number
- ACTRN12609000541202
- Lead Sponsor
- Department of Health, South Australia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Pituitary patients: Clearly diagnosed with either ACTH sufficiency/deficiency
Normal volunteers: Age 20-80 yrs
Exclusion Criteria
Pregnancy, advanced malignancy, active infection, liver failure
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sensitivity of basal and synacthen-stimulated free cortisol (by mass spectrometry) to diagnose adrenal insufficiency. The normal subjects will be used to define the reference range for cortisol by mass spectrometry. The definition of pituitary subjects as either ACTH sufficient or deficient will be historical and based on the assessment of the HPA axis after pituitary surgery using current gold standard assessments (e.g insulin tolerance test or unequivocally normal or abnormal morning cortisol).[At time of study (cross-sectional study)]
- Secondary Outcome Measures
Name Time Method Sensitivity of basal and synacthen-stimulated total cortisol (by mass spectrometry) to diagnose adrenal insufficiency. The normal subjects will be used to define the reference range for cortisol by mass spectrometry. The definition of pituitary subjects as either ACTH sufficient or deficient will be historical and based on the assessment of the HPA axis after pituitary surgery using current gold standard assessments (e.g insulin tolerance test or unequivocally normal or abnormal morning cortisol).[At time of study (cross-sectional study)]