Quantitative and qualitative analysis of cortisol and adrenocorticotrophic hormone (ACTH) secretion in patients with subclinical Cushing syndrome (SCS) and bilaterally enlarged adrenal glands

• Conditions: Subclinical Cushing Syndrome; Subclinical Hypercortisolism; 10001353

• Registration Number: NL-OMON31116
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Patients known at the outpatient clinic of Endocrine Diseases in the UMCN St. Radboud, with subclinical Cushing syndrome with bilateral adrenal pathology

Exclusion Criteria

Patients with SCS in whom adrenalectomy has been done, and patients with SCS and unilateral adrenal involvement and patients with SCS due to pituitary pathology

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cortisol and ACTH rhythm expressed as frequency/amplitude and regularity of<br /><br>cortisol and ACTH secretory pulses.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Comparance of cortisol and ACTH rhythm expressed as frequency/amplitude and<br /><br>regularity of cortisol and ACTH secretory pulses of patients with subclinical<br /><br>cushing syndrome to patients with full-blown Cushing syndrome and healthy<br /><br>controls, previously investigated by means of 10 minute sampling in the LUMC in<br /><br>Leiden.</p><br>