Conditioning cortisol and its psychophysiological effects
Completed
- Conditions
- Het onderzoek wordt bij gezonde proefpersonen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden nieuwe handvatten voor verklaringsmodellen en therapeutische interventies voor aandoeningen waarbij een verandering in de functie van de HPA-as optreedt.Not applicable
- Registration Number
- NL-OMON47397
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
healthy, female, premenopausal, 18-30 years of age
Exclusion Criteria
Somatic and/or psychiatric diseases, symptoms of infection, use of medication (including oral contraceptives), recent major stressful life events
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the AUCg of cortisol during rest in the evocation<br /><br>phase.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters are the AUCg of cortisol during exposure to a<br /><br>validated short-term psychosocial stress task, as well as the autonomic<br /><br>parameters alpha-amylase, heart rate, and skin conductance, and the<br /><br>psychological parameter self-reported well-being during the evocation phase.<br /><br>Additionally, to explore the possible influence of genotype on the effects of<br /><br>conditioning, the 5-HTTLPR genotype and other candidate genotypes will be<br /><br>assessed.</p><br>