Correlation between cortisol hormone levels and cardiovascular risk in healthy adults

Not Applicable

Recruiting

• Conditions: insulin sensitivity; cardiovascular disease; Metabolic and Endocrine - Diabetes; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12615000739516
• Lead Sponsor: Assoc Prof Morton Burt

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-07-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Age >40 years and living independently in the community

Exclusion Criteria

History of pituitary or adrenal adenoma, taking oral glucocorticoids within the last month, current Atrial fibrillation, Raynaud’s phenomenon, Rheumatoid arthritis, taking oral oestrogen (e.g oral contraceptive or hormone replacement therapy), severe asthma (hospital admission in the last 5 years)

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary end point is the difference in reactive hyperaemia index measured using endo-PAT 2000 device between high and low cortisol responders[Reactive hyperaemia index will be assessed before and 2 hours after meal in all participants]

Secondary Outcome Measures

Name	Time	Method
insulin sensitivity using matsuda index[Insulin and glucose levels will be checked fasting and at 30, 60, 90 and 120 minutes after a mixed-meal and insulin sensitivity calculated using matsuda index ];Augmentation index [Augmentation index, a validated marker of systemic arterial stiffness will be assessed fasting and at 30, 60, 90 and 120 minutes post mixed-meal using a sphygmacor hyaemodynamic device <br>];Pulse wave velocity[Pulse wave velocity will be assessed fasting and at 90 minutes post mixed-meal using a sphygmacor haemodynamic device];Arginine metabolism[Arginine and its metabolites (citrulline, homoarginine, ornithine), and inhibitors of nitric oxide synthase (ADMA, MMA and SDMA) will be estimated fasting and at 2 hours post mixed meal];insulin secretion[Insulin secretion will be assessed using C-peptide deconvolution method from glucose, insulin and C-peptide levels estimated fasting and at half an hour intervals for 2 hours after a mixed meal]