Acute effects of 40 mg cortisol on emotion and cognition.
Completed
- Conditions
- biased cognitionselective attention10002861
- Registration Number
- NL-OMON44224
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
good physical health
17female
Exclusion Criteria
-use of prescription medication
-history of psychiatric, neurologic, or endocrine illness
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Performance (measured response times and accuracy scores) on various<br /><br>computerized tasks that measure attentional processing of emotional stimuli and<br /><br>executive cognitive performance. Also, self-reported cognitive interference<br /><br>during cognitive performance will be assessed. Finally, we will<br /><br>Assess resting-state EEG, salivary cortisol concentration, several<br /><br>self-reported psychological trait questionnaires and self-reported state<br /><br>anxiety and state attentional control.</p><br>
- Secondary Outcome Measures
Name Time Method <p>As a secondary aim, we will examine whether the effects of hydrocortisone on<br /><br>cognition are moderated by frontal EEG theta/beta ratio (or other trait<br /><br>characteristics such as trait attentional control as assessed by the ACS). In<br /><br>order to test this hypotheses, mixed ANCOVAs will be performed with the same<br /><br>between and within-subjects factors, as described in section 10.1, and<br /><br>theta/beta ratio (or ACS) as covariate (s). If applicable,<br /><br>follow-up simple slope analyses will be performed to reveal the nature of<br /><br>significant moderational interactions.<br /><br>The negative relationship between theta/beta ratio and attentional control will<br /><br>be tested with Pearson's correlations and partial correlations, controlling for<br /><br>trait anxiety.</p><br>