Strain Index Ratio as a Biomarker for Mechanical Complication of Hemorrhagic Myocardial Infarction

Completed

• Conditions: Myocardial Stunning; Hemorrhagic Myocardial Infarction; Myocardial Hemorrhage; Myocardial Reperfusion Injury; Myocardial Rupture (Post Infarct); Acute Myocardial Infarction

• Registration Number: NCT06450912
• Lead Sponsor: Rohan Dharmakumar

Brief Summary

Hemorrhagic Myocardial infarctions are at high risk for mechanical complications including cardiac rupture. Prediction of vulnerable myocardial segments is an important step for the stratification of hemorrhagic MI patients. Wall motion index ratio is an important parameter to determine regions of high vulnerability within the 17-segment LV model of hemorrhagic MI.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-01
• Primary Completion: 2024-06-01
• Study Completion: 2024-06-01
• Study First Submitted: 2024-06-04
• Study First Submitted QC: 2024-06-07
• Study First Posted: 2024-06-10
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-04
• Last Update Posted: 2025-04-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• Index STEMI
• Primary PCI
• Able to complete Cardiac MR - STRAIN Protocol

Exclusion Criteria

• Contraindication to CMR (Contrast Hypersensitivity, Metallic Implants, Abnormal Rhythms, breathing difficulties)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Wall Strain Index for Potential Detection of Intramyocardial Hemorrhage	48 hours Post-PCI	Difference in Wall Strain Index values between patients with intramyocardial hemorrhage and those without, confirmed by cardiac MRI.
Wall Strain Index in Detecting the Severity of Intramyocardial Hemorrhage	48 hours Post-PCI	Relationship between initial Wall Strain Index measurements and the volume of intramyocardial hemorrhage quantified by cardiac MRI
Wall Strain Index Ratio in Identification of Vulnerable LV Segments for Cardiac Rupture	48 hours Post-PCI	Wall Strain Index Ratio for circumferential and longitudinal strain in identifying vulnerable hemorrhagic left ventricular segments at risk for rupture

Trial Locations

Locations (1)

Krannert Cardiovascular Research Center, Indiana University School of Medicine; 🇺🇸 Indianapolis, Indiana, United States