Thermal Imaging in Liver Disease.

Completed

• Conditions: Liver Diseases
• Interventions: Diagnostic Test: Thermal imaging

• Registration Number: NCT03279419
• Lead Sponsor: University of Edinburgh

Brief Summary

This is a feasibility study, to assess if thermal imaging and/or near infrared imaging will be useful in identifying changes in the peripheral circulation in patients with different stages of liver disease.

The aim of this study is to use new and advanced thermal imaging techniques to identify changes in the peripheral circulation and hand temperature in patients with liver disease. These changes could be used as a non-invasive marker of the severity and progression of liver disease. Thermal imaging will also be used to assess the changes in the peripheral vasculature with the use of terlipressin, a drug used as treatment for specific complications of liver disease.

Patients with acute or chronic liver disease from any aetiology will be recruited, along with patients without liver disease as healthy controls. Patients with disease or on drugs known to affect the peripheral vasculature will be excluded.

All studies will be performed in a ward setting in the Royal Infirmary of Edinburgh. The subjects will be required for up to three sessions, each lasting 30 minutes. The session will involve static thermal images being taken, and video images of the hands warming up after being cooled for 30 seconds in water at a temperature of 7 degrees Celsius. If the patient is receiving terlipressin therapy, static images will be taken before, during and after terlipressin therapy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-09-08
• Study First Submitted QC: 2017-09-08
• Study First Posted: 2017-09-12
• Study Start: 2019-09-01
• Primary Completion: 2019-09-01
• Study Completion: 2019-12-01
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-17
• Last Update Posted: 2024-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• diagnosis of chronic liver disease (any stage)
• diagnosis of acute liver disease (any aetiology)

Exclusion Criteria

• on drugs known to affect peripheral circulation
• conditions known to affect peripheral circulation e.g. Raynauds

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Normal	Thermal imaging	15 patients without liver disease, and without any other disease or drug known to affect the peripheral circulation. Serial static images to be taken at up to 3 time points using thermal imaging camera. Video images using thermal camera will be used to capture warming of one hand after cooling.
Liver disease	Thermal imaging	15 patients with acute or chronic liver disease of any aetiology. Serial static images to be taken at up to 3 time points using thermal imaging camera. Video images using thermal camera will be used to capture warming of one hand after cooling. Patient may or may not be receiving terlipressin therapy.

Primary Outcome Measures

Name	Time	Method
Changes in peripheral vasculature as assessed by thermal imaging	2 years

Secondary Outcome Measures

Name	Time	Method
Changes in peripheral vasculature in response to terlipressin therapy.	2 years

Trial Locations

Locations (1)

Univerity of Edinburgh and NHS Lothian; 🇬🇧 Edinburgh, United Kingdom