CTRI/2011/11/002138
Recruiting
Phase 4
A Pilot Study To Evaluate The Effect Of N-Acetyl Cysteine (NAC) On The Bronchodilator Response With Inhaled Salbutamol And Ipratropium In Patients With Chronic Obstructive Pulmonary Disease (COPD)
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Health Condition 1: null- Chronic Obstructive Pulmonary Disease
- Sponsor
- Cipla Ltd
- Enrollment
- 30
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult males or females with a diagnosis of Chronic Obstructive Pulmonary Disease
- •COPD defined as FEV1/FVC \< 0\.7 and FEV1 \< 80% predicted
Exclusion Criteria
- •Previous history of diagnosis of asthma
- •Previous history of atopy except controlled allergic rhinitis
- •History of concomitant pulmonary disease
- •Patients with bronchogenic carcinoma
- •Patients having known hypersensitivity to NAC
- •Patients with peripheral eosinophill count more than 600/µl of blood.
- •Patients already on NAC therapy or any mucolytic agent
- •Patients having history suggestive of high antioxidant intake through nutritional route
- •COPD with exacerbation within the previous three months requiring oral steroids, nebulised bronchodilator, antibiotics or an emergency visit to the doctor
- •Patients having uncontrolled allergic rhinitis
Outcomes
Primary Outcomes
Not specified
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